Tuesday, June 30, 2015


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Greater understanding of drugs used during pregnancy is needed to protect the health of pregnant women and their infants

Find out what OPRU researchers are doing to study drug dosing, safety,and efficacy during pregnancy

OPRU Description

The Obstetric-Fetal Pharmacology Research Units (OPRU) Network is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to conduct pharmacology research to enhance understanding of obstetrical pharmacokinetics (PK) and pharmacodynamics (PD), and to improve appropriate therapeutics during pregnancy. There are currently four clinical research sites and a data coordination and analysis center funded to conduct coordinated research on basic questions regarding pharmacology during pregnancy. Findings from these basic, translational, and clinical pharmacological studies will better enable clinicians to protect the health of pregnant women, while improving birth outcomes and reducing infant mortality.

Current research focuses on PK and PD of oral hypoglycemics for treatment of gestational diabetes, agents thought to alter uterine activity, pravastatin for treatment of preeclampsia, and a broad range of drugs used during pregnancy (antibiotics, antidepressants, etc). Investigators at the four Network sites provide a multidisciplinary perspective for these questions and utilize a diverse array of preclinical and clinical approaches to explore the questions addressed using in vitro to in vivo models. Such a multi-disciplinary approach is necessary to improve our understanding of the complicated interplay of environmental and genetic factors that influence PK and PD during pregnancy and lactation.

For more information about the Obstetric-Fetal Pharmacology Research Units (OPRU) Network, please contact:

Linda Morris Brown
Principal Investigator
RTI International
6110 Executive Blvd, Suite 902
Rockville, Maryland 20852
Telephone: (301) 816-4626
Fax: (301) 230-4647
Email: lindabrown@rti.org
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