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Last updated: October 25, 2013
Protocols

Studies conducted by the OPRU Network include:
  • Pharmacokinetics of Understudied Drugs Used During Pregnancy (Opportunistic)
  • Pharmacokinetics and Pharmacodynamics of Glyburide in Gestational Diabetics and Type 2 Diabetics (Glyburide)
  • A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy (Caproate)
  • Levothyroxine Pharmacokinetics Based on State-of-the-Art Analytic Methods (Levothyroxine)
  • A Double-Blind Multicenter Randomized Placebo Controlled Trial of the Efficacy of Diclectin® for Nausea and Vomiting of Pregnancy
  • Clonidine Hemodynamic Effects During Pregnancy
  • Effects of Pregnancy on Metformin Pharmacokinetics
  • Human Placental Transfer of Metformin and Rosiglitazone
  • Human Placental Transfer of Glyburide
  • Placental Biotransformation of Glyburide During Pregnancy: Implications for identification of the enzymes and metabolites
  • Placental Transfer and Biotransformation of 17-Hydroxyprogestrone Caproate
  • Bcrp1/Abcg2 and Fetal Distribution of Glyburide
  • Effects of Pregnancy on Clonidine Pharmacokinetics
  • Dacarbazine and the Effects of Pregnancy on CYP1A2
  • Cyclosporine and Placental P-glycoprotein Activity
  • 17-OHPC Basic Science Studies
  • Gestational-Age-Dependent Changes in Placental P-glycoprotein Activity in the non-human primate, Macaca nemestrina
  • Pharmacokinetics of Oseltamivir Among Pregnant and Nonpregnant Women
  • Impact of Glucocorticoid Polymorphisms on Markers of Neonatal Respiratory Disease After Antenatal Betamethasone Administration
  • Duration of Cisplatin Excretion in Breast Milk
  • Tacrolimus Concentrations During Pregnancy and Postpartum
  • Transplacental Transfer of Vancomycin and Televancin

Clinical OPRU Network studies currently enrolling:
  • Pravastatin for the Prevention of Preeclampsia in High-Risk Women: A Phase I Pilot Study
  • Glyburide and Metformin for Gestational Diabetes Mellitus
  • Determining the Pharmacodynamic Impact of Vaginal and IM Progestins on the Cervix

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